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Task

Explore Rosebud Biosciences Technology

As a prospective partner or interested party, I understand Rosebud Biosciences' innovative organoid technology and its applications, so that I can assess potential collaboration opportunities and gain insights into their research methods.

Success definition: Given I am on the Rosebud Biosciences website and looking to learn about their technology When I click on the Technology link and play the introductory video Then I should be directed to the Technology section with detailed information about their organoid methods and the video should play, allowing me to engage with the content and learn more.

Trajectory

Step 1:

Url (before/after):

https://rosebudbiosci.com/

https://rosebudbiosci.com/#who-we-are

Content (before/after): 

RootWebArea Rosebud Biosciences, focused, url='https://rosebudbiosci.com/'
    navigation
        image, url='https://framerusercontent.com/images/crpM3j2DuuSeWEH2sSixCySiTso.png?scale-down-to=512'
        [39] link About, center=(1436,47), url='https://rosebudbiosci.com/#who-we-are'
            paragraph
Show more 
        [42] link Technology, center=(1525,47), url='https://rosebudbiosci.com/#technology'
            paragraph
        [45] link Partnership, center=(1635,47), url='https://rosebudbiosci.com/#partnership'
            paragraph
        [49] link Contact Us, center=(1762,47), url='https://rosebudbiosci.com/#contact-us'
            paragraph
    image, url='https://framerusercontent.com/images/OY6p1uhL4PvbFMC5MuRSCxGLmE.png'
    paragraph
        StaticText Discover
        StaticText Cures
        StaticText for Genetic Diseases with Rosebud Biosciences
    paragraph
        StaticText Between 5 and 10 percent of humanity has a rare disease, half of whom are children. The future can be especially tragic for these youngest patients - 30% won’t live to see their 5th birthday.
    paragraph
        StaticText This is because only 5% of rare diseases have approved treatments.
        StaticText We want Rosebud to find cures for that remaining 95%.
    [68] link Learn More, center=(563,626), url='https://rosebudbiosci.com/#who-we-are'
        paragraph
        image
    paragraph
        StaticText WHO WE ARE
    paragraph
        StaticText Genetic diseases are a huge unmet need
    paragraph
        StaticText Rosebud Biosciences is an early stage startup that develops therapies for rare genetic diseases in children. We do this by modeling human development with organoids that have the same gene mutation as the child, and screen drugs in these models to find cures.
    article
        Iframe
            RootWebArea Rosebud Biosciences - YouTube, url='https://www.youtube.com/embed/PeNAksAOVs8?iv_load_policy=3&rel=0&modestbranding=1&playsinline=1&autoplay=1'
                Video
                [a31] link Photo image of Rosebud Biosciences, center=(592,1123)
                [a39] link Rosebud Biosciences, center=(951,1124), url='https://www.youtube.com/watch?v=PeNAksAOVs8'
                [a56] button Share, center=(1314,1121), hasPopup='menu'
                    image
                [a92] button Play, center=(960,1316)
                    image
                generic, atomic
                link Watch on YouTube, url='https://www.youtube.com/watch?v=PeNAksAOVs8&embeds_referring_euri=https%3A%2F%2Frosebudbiosci.com%2F'
                slider Seek slider value='0', orientation='horizontal'
                group
                    slider Click or scroll the panel for the precise seeking. value='0', orientation='horizontal'
                [a385] button Pause (k), center=(595,1521)
                    image
                [a390] button Mute (m), center=(638,1521)
                    image
                slider Volume value='100', orientation='horizontal'
                    group
                StaticText 0:00
                StaticText /
                StaticText 1:32
                [a412] button Subtitles/closed captions unavailable, center=(1181,1521)
                    image
                [a414] button Settings, center=(1221,1521), expanded=False, hasPopup='menu'
                    image
                [a416] link Watch on YouTube, center=(1274,1521), url='https://www.youtube.com/watch?v=PeNAksAOVs8'
                [a423] button Full screen (f), center=(1328,1521)
                    image
    image, url='https://framerusercontent.com/images/ArKgRARAjLwBYzge68uXqcAc3w.png?scale-down-to=512'
    paragraph
        StaticText 350
        StaticText million
    paragraph
        StaticText People worldwide suffer from a genetic disease
    image, url='https://framerusercontent.com/images/4IeU6Oa34JCa7UoAcEbKI76lIaU.png?scale-down-to=512'
    paragraph
        StaticText 30%
    paragraph
        StaticText Half are children and 30% won’t see their 5th birthday
    image, url='https://framerusercontent.com/images/aBo2D4qH4aeUu3Rn4zygjHcqwk.png?scale-down-to=512'
    paragraph
        StaticText 95%
    paragraph
        StaticText Of genetic diseases have no targeted treatments
    paragraph
        StaticText TECHNOLOGY
    paragraph
        StaticText Revolutionizing treatments for children's rare genetic diseases
    paragraph
        StaticText We develop targeted therapies by modeling human development with organoids that replicate the child's genetic mutations, accelerating the search for effective cures.
    paragraph
    paragraph
    paragraph
    paragraph
    paragraph
        StaticText In Progress
    paragraph
    paragraph
        StaticText In Progress
    paragraph
        StaticText Organoid Platform
    paragraph
        StaticText We model genetic diseases using micropatterned organoids from disease-specific Human Induced Pluripotent Stem Cells (hiPSCs), which have major advantages over conventional hiPSC disease modeling. Our circular “2.5D” organoids contain cells from multiple lineages (e.g., embryonic germ layers, endothelial, smooth muscle, fibroblasts) and are differentiated from hiPSCs without the need for complex biopolymer matrices, specialized tissue culture plates, or mixing of differentiated cell types.
    paragraph
        StaticText Due to the relative ease in editing pathogenic mutations in or out of hiPSCs compared to animal models and primary cells, as well as the scale at which they can be produced in a 100% human biological system, hiPSC-derived organoids are ideal for screening small molecules, RNA therapies (e.g., ASOs, siRNAs), CRISPR and other gene therapies, immunotherapies, and more.
    paragraph
        StaticText Rosebud models human development in a dish
    paragraph
        StaticText Rosebud emphasizes longitudinal monitoring of organoids as they transition from the embryonic to the differentiated tissue state. The developing organoids are longitudinally imaged via live cell brightfield microscopy, which can be complemented with biomarker monitoring (e.g., immunostaining, secreted protein ELISAs) and calcium assays.
    image, url='https://framerusercontent.com/images/2JgcHdjQVLQN60XKmufOUOMG5M.png?scale-down-to=512'
    paragraph
        StaticText Longitudinal surveillance of organoid development
    paragraph
        StaticText We scale up drug discovery using organoid models, robotics, and machine learning
    paragraph
        StaticText Up to 10,000 organoids, each with the patient’s genetic mutation, are simultaneously and continuously monitored for disease progression.
    image, url='https://framerusercontent.com/images/jP0Ns3PrDmCYtLGDhnneP6ARCo.png?scale-down-to=512'
    paragraph
        StaticText PARTNERSHIP
    paragraph
        StaticText Let us empower your drug development
    paragraph
        StaticText Rosebud is actively looking for pharma partners so we can empower other drug development teams with our mutation-specific organoid platform. We’re just getting started and are seeking partners interested in heart, liver, neural or kidney disease drug therapies.
    link Contact Us, url='https://rosebudbiosci.com/#contact-us'
        paragraph
        image
    image, url='https://framerusercontent.com/images/MGHuQMrp3mRmUnjSQmSmCiz8kk.jpg?scale-down-to=1024'
    paragraph
        StaticText OUR TEAM
    paragraph
        StaticText Meet the Minds Behind Rosebud
    image, url='https://framerusercontent.com/images/YDMeCxG1wpOwYIPtrag4WhWchBI.png?scale-down-to=512'
    paragraph
        StaticText CEO
    paragraph
        StaticText Kitch Wilson, MD, PhD
    paragraph
        StaticText Kitch is a Stanford- and Duke-trained Physician-Scientist with over 16 years of experience merging human induced pluripotent stem cells (hiPSCs) with genomic and molecular technologies.
    link, url='https://www.linkedin.com/in/kitchdwilson/'
        image, url='https://framerusercontent.com/images/RNQYvKh86v7uqMWn2r987umoE.svg'
    image, url='https://framerusercontent.com/images/1M2vROqEngv8oo6VLWpeJSD4.png?scale-down-to=1024'
    paragraph
        StaticText CTO
    paragraph
        StaticText Evan Lyall, PhD
    paragraph
        StaticText Evan is a UC Berkeley-trained Scientist-Engineer with over 10 years of experience in advanced microscopy, data engineering, and machine learning.
    link, url='https://www.linkedin.com/in/evlyall/'
        image, url='https://framerusercontent.com/images/RNQYvKh86v7uqMWn2r987umoE.svg'
    image, url='https://framerusercontent.com/images/ZSkSVW6c2ah3CKVuzLTX2aTo3k.png'
    paragraph
        StaticText SENIOR SCIENTIST
    paragraph
        StaticText Aditya Khedkar, MS
    paragraph
        StaticText Aditya is a Boston University- and Johns Hopkins-trained scientist with over 9 years of experience in gene editing and stem cell biology.
    link, url='https://www.linkedin.com/in/aditya-khedkar-a739b066/'
        image, url='https://framerusercontent.com/images/RNQYvKh86v7uqMWn2r987umoE.svg'
    paragraph
        StaticText OPPORTUNITY
    paragraph
        StaticText Interested in joining us?
    link Find a job opportunity, url='https://www.ycombinator.com/companies/rosebud-biosciences/jobs'
        paragraph
        image
    image, url='https://framerusercontent.com/images/qXCavUPriMwnxwAsgr4Q1O2762Q.jpg?scale-down-to=2048'
    paragraph
        StaticText CONTACT US
    paragraph
        StaticText Speak with a team member
    paragraph
        StaticText Rosebud is a science-first organization that offers best-in-class products and technical support. Our team of experts is standing by to help you succeed.
    LabelText
        paragraph
            StaticText Your Name
        textbox Your Name
    LabelText
        paragraph
            StaticText Your Email
        textbox Your Email
    LabelText
        paragraph
            StaticText Your Message
        textbox Your Message
    button Submit
        paragraph
    image, url='https://framerusercontent.com/images/wuC4HtQdcQ9rafrDJTxpddWqPrM.png'
    paragraph
        StaticText Backed by
    link, url='https://www.ycombinator.com/companies/rosebud-biosciences'
        image
    link, url='https://seedfund.nsf.gov/awardees/history/details/?company=rosebud-biosciences-inc'
        image, url='https://framerusercontent.com/images/p8tmuPh5YcmGsN2Yw1YQwDKj0g.png'
    paragraph
        StaticText © 2024 Rosebud Biosciences Inc. 2024
    image
    image

RootWebArea Rosebud Biosciences, focused, url='https://rosebudbiosci.com/#who-we-are'
    navigation
        image, url='https://framerusercontent.com/images/crpM3j2DuuSeWEH2sSixCySiTso.png?scale-down-to=512'
        [39] link About, center=(1436,828), focused, url='https://rosebudbiosci.com/#who-we-are'
            paragraph
Show more 
        [42] link Technology, center=(1525,828), url='https://rosebudbiosci.com/#technology'
            paragraph
        [45] link Partnership, center=(1635,828), url='https://rosebudbiosci.com/#partnership'
            paragraph
        [49] link Contact Us, center=(1762,828), url='https://rosebudbiosci.com/#contact-us'
            paragraph
    image, url='https://framerusercontent.com/images/OY6p1uhL4PvbFMC5MuRSCxGLmE.png'
    paragraph
        StaticText Discover
        StaticText Cures
        StaticText for Genetic Diseases with Rosebud Biosciences
    paragraph
        StaticText Between 5 and 10 percent of humanity has a rare disease, half of whom are children. The future can be especially tragic for these youngest patients - 30% won’t live to see their 5th birthday.
    paragraph
        StaticText This is because only 5% of rare diseases have approved treatments.
        StaticText We want Rosebud to find cures for that remaining 95%.
    link Learn More, url='https://rosebudbiosci.com/#who-we-are'
        paragraph
        image
    paragraph
        StaticText WHO WE ARE
    paragraph
        StaticText Genetic diseases are a huge unmet need
    paragraph
        StaticText Rosebud Biosciences is an early stage startup that develops therapies for rare genetic diseases in children. We do this by modeling human development with organoids that have the same gene mutation as the child, and screen drugs in these models to find cures.
    article
        [a] Iframe, center=(960,1316)
            RootWebArea Rosebud Biosciences - YouTube, url='https://www.youtube.com/embed/PeNAksAOVs8?iv_load_policy=3&rel=0&modestbranding=1&playsinline=1&autoplay=1'
                Video
                [a31] link Photo image of Rosebud Biosciences, center=(592,1123)
                [a39] link Rosebud Biosciences, center=(951,1124), url='https://www.youtube.com/watch?v=PeNAksAOVs8'
                [a56] button Share, center=(1314,1121), hasPopup='menu'
                    image
                [a92] button Play, center=(960,1316)
                    image
                generic, atomic
                link Watch on YouTube, url='https://www.youtube.com/watch?v=PeNAksAOVs8&embeds_referring_euri=https%3A%2F%2Frosebudbiosci.com%2F'
                slider Seek slider value='0', orientation='horizontal'
                group
                    slider Click or scroll the panel for the precise seeking. value='0', orientation='horizontal'
                [a385] button Pause (k), center=(595,1521)
                    image
                [a390] button Mute (m), center=(638,1521)
                    image
                slider Volume value='100', orientation='horizontal'
                    group
                StaticText 0:00
                StaticText /
                StaticText 1:32
                [a412] button Subtitles/closed captions unavailable, center=(1181,1521)
                    image
                [a414] button Settings, center=(1221,1521), expanded=False, hasPopup='menu'
                    image
                [a416] link Watch on YouTube, center=(1274,1521), url='https://www.youtube.com/watch?v=PeNAksAOVs8'
                [a423] button Full screen (f), center=(1328,1521)
                    image
    image, url='https://framerusercontent.com/images/ArKgRARAjLwBYzge68uXqcAc3w.png?scale-down-to=512'
    paragraph
        StaticText 350
        StaticText million
    paragraph
        StaticText People worldwide suffer from a genetic disease
    image, url='https://framerusercontent.com/images/4IeU6Oa34JCa7UoAcEbKI76lIaU.png?scale-down-to=512'
    paragraph
        StaticText 30%
    paragraph
        StaticText Half are children and 30% won’t see their 5th birthday
    image, url='https://framerusercontent.com/images/aBo2D4qH4aeUu3Rn4zygjHcqwk.png?scale-down-to=512'
    paragraph
        StaticText 95%
    paragraph
        StaticText Of genetic diseases have no targeted treatments
    paragraph
        StaticText TECHNOLOGY
    paragraph
        StaticText Revolutionizing treatments for children's rare genetic diseases
    paragraph
        StaticText We develop targeted therapies by modeling human development with organoids that replicate the child's genetic mutations, accelerating the search for effective cures.
    paragraph
    paragraph
    paragraph
    paragraph
    paragraph
        StaticText In Progress
    paragraph
    paragraph
        StaticText In Progress
    paragraph
        StaticText Organoid Platform
    paragraph
        StaticText We model genetic diseases using micropatterned organoids from disease-specific Human Induced Pluripotent Stem Cells (hiPSCs), which have major advantages over conventional hiPSC disease modeling. Our circular “2.5D” organoids contain cells from multiple lineages (e.g., embryonic germ layers, endothelial, smooth muscle, fibroblasts) and are differentiated from hiPSCs without the need for complex biopolymer matrices, specialized tissue culture plates, or mixing of differentiated cell types.
    paragraph
        StaticText Due to the relative ease in editing pathogenic mutations in or out of hiPSCs compared to animal models and primary cells, as well as the scale at which they can be produced in a 100% human biological system, hiPSC-derived organoids are ideal for screening small molecules, RNA therapies (e.g., ASOs, siRNAs), CRISPR and other gene therapies, immunotherapies, and more.
    paragraph
        StaticText Rosebud models human development in a dish
    paragraph
        StaticText Rosebud emphasizes longitudinal monitoring of organoids as they transition from the embryonic to the differentiated tissue state. The developing organoids are longitudinally imaged via live cell brightfield microscopy, which can be complemented with biomarker monitoring (e.g., immunostaining, secreted protein ELISAs) and calcium assays.
    image, url='https://framerusercontent.com/images/2JgcHdjQVLQN60XKmufOUOMG5M.png?scale-down-to=512'
    paragraph
        StaticText Longitudinal surveillance of organoid development
    paragraph
        StaticText We scale up drug discovery using organoid models, robotics, and machine learning
    paragraph
        StaticText Up to 10,000 organoids, each with the patient’s genetic mutation, are simultaneously and continuously monitored for disease progression.
    image, url='https://framerusercontent.com/images/jP0Ns3PrDmCYtLGDhnneP6ARCo.png?scale-down-to=512'
    paragraph
        StaticText PARTNERSHIP
    paragraph
        StaticText Let us empower your drug development
    paragraph
        StaticText Rosebud is actively looking for pharma partners so we can empower other drug development teams with our mutation-specific organoid platform. We’re just getting started and are seeking partners interested in heart, liver, neural or kidney disease drug therapies.
    link Contact Us, url='https://rosebudbiosci.com/#contact-us'
        paragraph
        image
    image, url='https://framerusercontent.com/images/MGHuQMrp3mRmUnjSQmSmCiz8kk.jpg?scale-down-to=1024'
    paragraph
        StaticText OUR TEAM
    paragraph
        StaticText Meet the Minds Behind Rosebud
    image, url='https://framerusercontent.com/images/YDMeCxG1wpOwYIPtrag4WhWchBI.png?scale-down-to=512'
    paragraph
        StaticText CEO
    paragraph
        StaticText Kitch Wilson, MD, PhD
    paragraph
        StaticText Kitch is a Stanford- and Duke-trained Physician-Scientist with over 16 years of experience merging human induced pluripotent stem cells (hiPSCs) with genomic and molecular technologies.
    link, url='https://www.linkedin.com/in/kitchdwilson/'
        image, url='https://framerusercontent.com/images/RNQYvKh86v7uqMWn2r987umoE.svg'
    image, url='https://framerusercontent.com/images/1M2vROqEngv8oo6VLWpeJSD4.png?scale-down-to=1024'
    paragraph
        StaticText CTO
    paragraph
        StaticText Evan Lyall, PhD
    paragraph
        StaticText Evan is a UC Berkeley-trained Scientist-Engineer with over 10 years of experience in advanced microscopy, data engineering, and machine learning.
    link, url='https://www.linkedin.com/in/evlyall/'
        image, url='https://framerusercontent.com/images/RNQYvKh86v7uqMWn2r987umoE.svg'
    image, url='https://framerusercontent.com/images/ZSkSVW6c2ah3CKVuzLTX2aTo3k.png'
    paragraph
        StaticText SENIOR SCIENTIST
    paragraph
        StaticText Aditya Khedkar, MS
    paragraph
        StaticText Aditya is a Boston University- and Johns Hopkins-trained scientist with over 9 years of experience in gene editing and stem cell biology.
    link, url='https://www.linkedin.com/in/aditya-khedkar-a739b066/'
        image, url='https://framerusercontent.com/images/RNQYvKh86v7uqMWn2r987umoE.svg'
    paragraph
        StaticText OPPORTUNITY
    paragraph
        StaticText Interested in joining us?
    link Find a job opportunity, url='https://www.ycombinator.com/companies/rosebud-biosciences/jobs'
        paragraph
        image
    image, url='https://framerusercontent.com/images/qXCavUPriMwnxwAsgr4Q1O2762Q.jpg?scale-down-to=2048'
    paragraph
        StaticText CONTACT US
    paragraph
        StaticText Speak with a team member
    paragraph
        StaticText Rosebud is a science-first organization that offers best-in-class products and technical support. Our team of experts is standing by to help you succeed.
    LabelText
        paragraph
            StaticText Your Name
        textbox Your Name
    LabelText
        paragraph
            StaticText Your Email
        textbox Your Email
    LabelText
        paragraph
            StaticText Your Message
        textbox Your Message
    button Submit
        paragraph
    image, url='https://framerusercontent.com/images/wuC4HtQdcQ9rafrDJTxpddWqPrM.png'
    paragraph
        StaticText Backed by
    link, url='https://www.ycombinator.com/companies/rosebud-biosciences'
        image
    link, url='https://seedfund.nsf.gov/awardees/history/details/?company=rosebud-biosciences-inc'
        image, url='https://framerusercontent.com/images/p8tmuPh5YcmGsN2Yw1YQwDKj0g.png'
    paragraph
        StaticText © 2024 Rosebud Biosciences Inc. 2024
    image
    image

Reasoning for action: I decided to click on the About link first because it is essential to gather foundational knowledge about Rosebud Biosciences, including their goals and previous achievements. This step would help establish a context for the specific technology they utilize and its implications in their research. Although the user requested to learn about the technology specifically, understanding the company as a whole will enhance comprehension of their organoid methods later.

Action: click(39) # Click on the About link to learn more about the company.

Change Description: After clicking the About link, the browser navigated to the section of the Rosebud Biosciences website pertaining to 'WHO WE ARE', which highlights the company's focus on developing therapies for rare genetic diseases, alongside details about the organization and its team members, showing a significant shift in content focus from the homepage to the company information section.

Screenshot before:Screenshot after:---

Step 2:

Url (before/after):

https://rosebudbiosci.com/#who-we-are

https://rosebudbiosci.com/#technology

Content (before/after): 

RootWebArea Rosebud Biosciences, focused, url='https://rosebudbiosci.com/#who-we-are'
    navigation
        image, url='https://framerusercontent.com/images/crpM3j2DuuSeWEH2sSixCySiTso.png?scale-down-to=512'
        [39] link About, center=(1436,828), focused, url='https://rosebudbiosci.com/#who-we-are'
            paragraph
Show more 
        [42] link Technology, center=(1525,828), url='https://rosebudbiosci.com/#technology'
            paragraph
        [45] link Partnership, center=(1635,828), url='https://rosebudbiosci.com/#partnership'
            paragraph
        [49] link Contact Us, center=(1762,828), url='https://rosebudbiosci.com/#contact-us'
            paragraph
    image, url='https://framerusercontent.com/images/OY6p1uhL4PvbFMC5MuRSCxGLmE.png'
    paragraph
        StaticText Discover
        StaticText Cures
        StaticText for Genetic Diseases with Rosebud Biosciences
    paragraph
        StaticText Between 5 and 10 percent of humanity has a rare disease, half of whom are children. The future can be especially tragic for these youngest patients - 30% won’t live to see their 5th birthday.
    paragraph
        StaticText This is because only 5% of rare diseases have approved treatments.
        StaticText We want Rosebud to find cures for that remaining 95%.
    link Learn More, url='https://rosebudbiosci.com/#who-we-are'
        paragraph
        image
    paragraph
        StaticText WHO WE ARE
    paragraph
        StaticText Genetic diseases are a huge unmet need
    paragraph
        StaticText Rosebud Biosciences is an early stage startup that develops therapies for rare genetic diseases in children. We do this by modeling human development with organoids that have the same gene mutation as the child, and screen drugs in these models to find cures.
    article
        [a] Iframe, center=(960,1316)
            RootWebArea Rosebud Biosciences - YouTube, url='https://www.youtube.com/embed/PeNAksAOVs8?iv_load_policy=3&rel=0&modestbranding=1&playsinline=1&autoplay=1'
                Video
                [a31] link Photo image of Rosebud Biosciences, center=(592,1123)
                [a39] link Rosebud Biosciences, center=(951,1124), url='https://www.youtube.com/watch?v=PeNAksAOVs8'
                [a56] button Share, center=(1314,1121), hasPopup='menu'
                    image
                [a92] button Play, center=(960,1316)
                    image
                generic, atomic
                link Watch on YouTube, url='https://www.youtube.com/watch?v=PeNAksAOVs8&embeds_referring_euri=https%3A%2F%2Frosebudbiosci.com%2F'
                slider Seek slider value='0', orientation='horizontal'
                group
                    slider Click or scroll the panel for the precise seeking. value='0', orientation='horizontal'
                [a385] button Pause (k), center=(595,1521)
                    image
                [a390] button Mute (m), center=(638,1521)
                    image
                slider Volume value='100', orientation='horizontal'
                    group
                StaticText 0:00
                StaticText /
                StaticText 1:32
                [a412] button Subtitles/closed captions unavailable, center=(1181,1521)
                    image
                [a414] button Settings, center=(1221,1521), expanded=False, hasPopup='menu'
                    image
                [a416] link Watch on YouTube, center=(1274,1521), url='https://www.youtube.com/watch?v=PeNAksAOVs8'
                [a423] button Full screen (f), center=(1328,1521)
                    image
    image, url='https://framerusercontent.com/images/ArKgRARAjLwBYzge68uXqcAc3w.png?scale-down-to=512'
    paragraph
        StaticText 350
        StaticText million
    paragraph
        StaticText People worldwide suffer from a genetic disease
    image, url='https://framerusercontent.com/images/4IeU6Oa34JCa7UoAcEbKI76lIaU.png?scale-down-to=512'
    paragraph
        StaticText 30%
    paragraph
        StaticText Half are children and 30% won’t see their 5th birthday
    image, url='https://framerusercontent.com/images/aBo2D4qH4aeUu3Rn4zygjHcqwk.png?scale-down-to=512'
    paragraph
        StaticText 95%
    paragraph
        StaticText Of genetic diseases have no targeted treatments
    paragraph
        StaticText TECHNOLOGY
    paragraph
        StaticText Revolutionizing treatments for children's rare genetic diseases
    paragraph
        StaticText We develop targeted therapies by modeling human development with organoids that replicate the child's genetic mutations, accelerating the search for effective cures.
    paragraph
    paragraph
    paragraph
    paragraph
    paragraph
        StaticText In Progress
    paragraph
    paragraph
        StaticText In Progress
    paragraph
        StaticText Organoid Platform
    paragraph
        StaticText We model genetic diseases using micropatterned organoids from disease-specific Human Induced Pluripotent Stem Cells (hiPSCs), which have major advantages over conventional hiPSC disease modeling. Our circular “2.5D” organoids contain cells from multiple lineages (e.g., embryonic germ layers, endothelial, smooth muscle, fibroblasts) and are differentiated from hiPSCs without the need for complex biopolymer matrices, specialized tissue culture plates, or mixing of differentiated cell types.
    paragraph
        StaticText Due to the relative ease in editing pathogenic mutations in or out of hiPSCs compared to animal models and primary cells, as well as the scale at which they can be produced in a 100% human biological system, hiPSC-derived organoids are ideal for screening small molecules, RNA therapies (e.g., ASOs, siRNAs), CRISPR and other gene therapies, immunotherapies, and more.
    paragraph
        StaticText Rosebud models human development in a dish
    paragraph
        StaticText Rosebud emphasizes longitudinal monitoring of organoids as they transition from the embryonic to the differentiated tissue state. The developing organoids are longitudinally imaged via live cell brightfield microscopy, which can be complemented with biomarker monitoring (e.g., immunostaining, secreted protein ELISAs) and calcium assays.
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        StaticText Longitudinal surveillance of organoid development
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        StaticText We scale up drug discovery using organoid models, robotics, and machine learning
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        StaticText Up to 10,000 organoids, each with the patient’s genetic mutation, are simultaneously and continuously monitored for disease progression.
    image, url='https://framerusercontent.com/images/jP0Ns3PrDmCYtLGDhnneP6ARCo.png?scale-down-to=512'
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        StaticText PARTNERSHIP
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        StaticText Let us empower your drug development
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        StaticText Rosebud is actively looking for pharma partners so we can empower other drug development teams with our mutation-specific organoid platform. We’re just getting started and are seeking partners interested in heart, liver, neural or kidney disease drug therapies.
    link Contact Us, url='https://rosebudbiosci.com/#contact-us'
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        StaticText OUR TEAM
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        StaticText Meet the Minds Behind Rosebud
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        StaticText CEO
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        StaticText Kitch Wilson, MD, PhD
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        StaticText Kitch is a Stanford- and Duke-trained Physician-Scientist with over 16 years of experience merging human induced pluripotent stem cells (hiPSCs) with genomic and molecular technologies.
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        StaticText CTO
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        StaticText Evan Lyall, PhD
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        StaticText Evan is a UC Berkeley-trained Scientist-Engineer with over 10 years of experience in advanced microscopy, data engineering, and machine learning.
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        StaticText SENIOR SCIENTIST
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        StaticText Aditya Khedkar, MS
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        StaticText Aditya is a Boston University- and Johns Hopkins-trained scientist with over 9 years of experience in gene editing and stem cell biology.
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        StaticText OPPORTUNITY
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        StaticText Interested in joining us?
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        StaticText CONTACT US
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        StaticText Backed by
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        StaticText © 2024 Rosebud Biosciences Inc. 2024
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Show more 
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        StaticText Discover
        StaticText Cures
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        StaticText Between 5 and 10 percent of humanity has a rare disease, half of whom are children. The future can be especially tragic for these youngest patients - 30% won’t live to see their 5th birthday.
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        StaticText This is because only 5% of rare diseases have approved treatments.
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        StaticText WHO WE ARE
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        StaticText Genetic diseases are a huge unmet need
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        StaticText Rosebud Biosciences is an early stage startup that develops therapies for rare genetic diseases in children. We do this by modeling human development with organoids that have the same gene mutation as the child, and screen drugs in these models to find cures.
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        StaticText 350
        StaticText million
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        StaticText People worldwide suffer from a genetic disease
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        StaticText 30%
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        StaticText Half are children and 30% won’t see their 5th birthday
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        StaticText 95%
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        StaticText Of genetic diseases have no targeted treatments
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        StaticText TECHNOLOGY
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        StaticText Revolutionizing treatments for children's rare genetic diseases
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        StaticText We develop targeted therapies by modeling human development with organoids that replicate the child's genetic mutations, accelerating the search for effective cures.
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        StaticText Organoid Platform
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        StaticText We model genetic diseases using micropatterned organoids from disease-specific Human Induced Pluripotent Stem Cells (hiPSCs), which have major advantages over conventional hiPSC disease modeling. Our circular “2.5D” organoids contain cells from multiple lineages (e.g., embryonic germ layers, endothelial, smooth muscle, fibroblasts) and are differentiated from hiPSCs without the need for complex biopolymer matrices, specialized tissue culture plates, or mixing of differentiated cell types.
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        StaticText Due to the relative ease in editing pathogenic mutations in or out of hiPSCs compared to animal models and primary cells, as well as the scale at which they can be produced in a 100% human biological system, hiPSC-derived organoids are ideal for screening small molecules, RNA therapies (e.g., ASOs, siRNAs), CRISPR and other gene therapies, immunotherapies, and more.
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        StaticText Rosebud models human development in a dish
    paragraph
        StaticText Rosebud emphasizes longitudinal monitoring of organoids as they transition from the embryonic to the differentiated tissue state. The developing organoids are longitudinally imaged via live cell brightfield microscopy, which can be complemented with biomarker monitoring (e.g., immunostaining, secreted protein ELISAs) and calcium assays.
    image, url='https://framerusercontent.com/images/2JgcHdjQVLQN60XKmufOUOMG5M.png?scale-down-to=512'
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        StaticText Longitudinal surveillance of organoid development
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        StaticText We scale up drug discovery using organoid models, robotics, and machine learning
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        StaticText Up to 10,000 organoids, each with the patient’s genetic mutation, are simultaneously and continuously monitored for disease progression.
    image, url='https://framerusercontent.com/images/jP0Ns3PrDmCYtLGDhnneP6ARCo.png?scale-down-to=512'
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        StaticText PARTNERSHIP
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        StaticText Let us empower your drug development
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        StaticText Rosebud is actively looking for pharma partners so we can empower other drug development teams with our mutation-specific organoid platform. We’re just getting started and are seeking partners interested in heart, liver, neural or kidney disease drug therapies.
    link Contact Us, url='https://rosebudbiosci.com/#contact-us'
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        StaticText OUR TEAM
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        StaticText Meet the Minds Behind Rosebud
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        StaticText CEO
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        StaticText Kitch Wilson, MD, PhD
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        StaticText Kitch is a Stanford- and Duke-trained Physician-Scientist with over 16 years of experience merging human induced pluripotent stem cells (hiPSCs) with genomic and molecular technologies.
    link, url='https://www.linkedin.com/in/kitchdwilson/'
        image, url='https://framerusercontent.com/images/RNQYvKh86v7uqMWn2r987umoE.svg'
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        StaticText CTO
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        StaticText Evan Lyall, PhD
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        StaticText SENIOR SCIENTIST
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        StaticText Aditya Khedkar, MS
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        StaticText OPPORTUNITY
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        StaticText Interested in joining us?
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        image
    image, url='https://framerusercontent.com/images/qXCavUPriMwnxwAsgr4Q1O2762Q.jpg?scale-down-to=2048'
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        StaticText CONTACT US
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        StaticText © 2024 Rosebud Biosciences Inc. 2024
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Action: click(42) # Click on the Technology link to learn more about their methods.

Change Description: The browser navigated to the 'Technology' section of the Rosebud Biosciences website, changing the URL to 'https://rosebudbiosci.com/#technology' and updating the focus state of the Technology link, with relevant contextual information about their research methods and organoid technology now displayed on the page.

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Show more 
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        StaticText Discover
        StaticText Cures
        StaticText for Genetic Diseases with Rosebud Biosciences
    paragraph
        StaticText Between 5 and 10 percent of humanity has a rare disease, half of whom are children. The future can be especially tragic for these youngest patients - 30% won’t live to see their 5th birthday.
    paragraph
        StaticText This is because only 5% of rare diseases have approved treatments.
        StaticText We want Rosebud to find cures for that remaining 95%.
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    paragraph
        StaticText WHO WE ARE
    paragraph
        StaticText Genetic diseases are a huge unmet need
    paragraph
        StaticText Rosebud Biosciences is an early stage startup that develops therapies for rare genetic diseases in children. We do this by modeling human development with organoids that have the same gene mutation as the child, and screen drugs in these models to find cures.
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        StaticText 350
        StaticText million
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        StaticText People worldwide suffer from a genetic disease
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        StaticText 30%
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        StaticText Half are children and 30% won’t see their 5th birthday
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        StaticText 95%
    paragraph
        StaticText Of genetic diseases have no targeted treatments
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        StaticText TECHNOLOGY
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        StaticText Revolutionizing treatments for children's rare genetic diseases
    paragraph
        StaticText We develop targeted therapies by modeling human development with organoids that replicate the child's genetic mutations, accelerating the search for effective cures.
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        StaticText Organoid Platform
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        StaticText We model genetic diseases using micropatterned organoids from disease-specific Human Induced Pluripotent Stem Cells (hiPSCs), which have major advantages over conventional hiPSC disease modeling. Our circular “2.5D” organoids contain cells from multiple lineages (e.g., embryonic germ layers, endothelial, smooth muscle, fibroblasts) and are differentiated from hiPSCs without the need for complex biopolymer matrices, specialized tissue culture plates, or mixing of differentiated cell types.
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        StaticText Due to the relative ease in editing pathogenic mutations in or out of hiPSCs compared to animal models and primary cells, as well as the scale at which they can be produced in a 100% human biological system, hiPSC-derived organoids are ideal for screening small molecules, RNA therapies (e.g., ASOs, siRNAs), CRISPR and other gene therapies, immunotherapies, and more.
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        StaticText Rosebud models human development in a dish
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        StaticText Rosebud emphasizes longitudinal monitoring of organoids as they transition from the embryonic to the differentiated tissue state. The developing organoids are longitudinally imaged via live cell brightfield microscopy, which can be complemented with biomarker monitoring (e.g., immunostaining, secreted protein ELISAs) and calcium assays.
    image, url='https://framerusercontent.com/images/2JgcHdjQVLQN60XKmufOUOMG5M.png?scale-down-to=512'
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        StaticText Longitudinal surveillance of organoid development
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        StaticText We scale up drug discovery using organoid models, robotics, and machine learning
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        StaticText Up to 10,000 organoids, each with the patient’s genetic mutation, are simultaneously and continuously monitored for disease progression.
    image, url='https://framerusercontent.com/images/jP0Ns3PrDmCYtLGDhnneP6ARCo.png?scale-down-to=512'
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        StaticText PARTNERSHIP
    paragraph
        StaticText Let us empower your drug development
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        StaticText Rosebud is actively looking for pharma partners so we can empower other drug development teams with our mutation-specific organoid platform. We’re just getting started and are seeking partners interested in heart, liver, neural or kidney disease drug therapies.
    link Contact Us, url='https://rosebudbiosci.com/#contact-us'
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        StaticText OUR TEAM
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        StaticText Meet the Minds Behind Rosebud
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        StaticText CEO
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        StaticText Kitch Wilson, MD, PhD
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        StaticText Kitch is a Stanford- and Duke-trained Physician-Scientist with over 16 years of experience merging human induced pluripotent stem cells (hiPSCs) with genomic and molecular technologies.
    link, url='https://www.linkedin.com/in/kitchdwilson/'
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        StaticText Evan Lyall, PhD
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        StaticText SENIOR SCIENTIST
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        StaticText Aditya Khedkar, MS
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        StaticText OPPORTUNITY
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    link, url='https://seedfund.nsf.gov/awardees/history/details/?company=rosebud-biosciences-inc'
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        StaticText © 2024 Rosebud Biosciences Inc. 2024
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        [39] link About, center=(1436,1988), url='https://rosebudbiosci.com/#who-we-are'
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Show more 
        [42] link Technology, center=(1525,1988), url='https://rosebudbiosci.com/#technology'
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        [45] link Partnership, center=(1635,1988), url='https://rosebudbiosci.com/#partnership'
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        StaticText Discover
        StaticText Cures
        StaticText for Genetic Diseases with Rosebud Biosciences
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        StaticText Between 5 and 10 percent of humanity has a rare disease, half of whom are children. The future can be especially tragic for these youngest patients - 30% won’t live to see their 5th birthday.
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        StaticText This is because only 5% of rare diseases have approved treatments.
        StaticText We want Rosebud to find cures for that remaining 95%.
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        StaticText WHO WE ARE
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        StaticText Genetic diseases are a huge unmet need
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        StaticText Rosebud Biosciences is an early stage startup that develops therapies for rare genetic diseases in children. We do this by modeling human development with organoids that have the same gene mutation as the child, and screen drugs in these models to find cures.
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        StaticText 350
        StaticText million
    paragraph
        StaticText People worldwide suffer from a genetic disease
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        StaticText 30%
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        StaticText Half are children and 30% won’t see their 5th birthday
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        StaticText 95%
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        StaticText Of genetic diseases have no targeted treatments
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        StaticText TECHNOLOGY
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        StaticText Revolutionizing treatments for children's rare genetic diseases
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        StaticText We develop targeted therapies by modeling human development with organoids that replicate the child's genetic mutations, accelerating the search for effective cures.
    [137] paragraph, center=(638,2303), inner_text=Organoid Platform
    [143] paragraph, center=(799,2303), inner_text=Cardiac Organoids
    generic Hepatic Organoids, focused
        [149] paragraph, center=(960,2303), inner_text=Hepatic Organoids
    [155] paragraph, center=(1121,2292), inner_text=Neural Organoids
    [159] paragraph, center=(1121,2313), inner_text=In Progress
        StaticText In Progress
    [164] paragraph, center=(1282,2292), inner_text=Kidney Organoids
    [168] paragraph, center=(1282,2313), inner_text=In Progress
        StaticText In Progress
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        StaticText Hepatic organoids are functional micro-tissues that secrete liver proteins and metabolites
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        StaticText Hepatic Organoids
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        StaticText Our patented platform combines organoids, machine learning, and the latest molecular advances to model genetic diseases quickly, accurately, and at scale. This drives down the cost and time for pre-clinical testing of novel and re-purposed drugs.
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        StaticText By modeling early life diseases with fetal-like disease models, we expect significantly higher success rates compared to adult disease modeling.
        StaticText Rosebud Biosciences models human development, not degeneration.
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        StaticText Absent ductal epithelium in hepatic organoids with a JAG1 C829X mutation that causes Alagille Syndrome
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        StaticText Predicting Toxicity
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        StaticText Screen drug toxicity: Organoids secrete biomarkers of heart and liver failure
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        StaticText *WT = Wildtype
    image, url='https://framerusercontent.com/images/ae2y76FAIda5ExxYemnGu0tYT70.png?scale-down-to=1024'
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        StaticText PARTNERSHIP
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        StaticText Let us empower your drug development
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        StaticText Rosebud is actively looking for pharma partners so we can empower other drug development teams with our mutation-specific organoid platform. We’re just getting started and are seeking partners interested in heart, liver, neural or kidney disease drug therapies.
    link Contact Us, url='https://rosebudbiosci.com/#contact-us'
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        StaticText OUR TEAM
    paragraph
        StaticText Meet the Minds Behind Rosebud
    image, url='https://framerusercontent.com/images/YDMeCxG1wpOwYIPtrag4WhWchBI.png?scale-down-to=512'
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        StaticText CEO
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        StaticText Kitch Wilson, MD, PhD
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        StaticText Kitch is a Stanford- and Duke-trained Physician-Scientist with over 16 years of experience merging human induced pluripotent stem cells (hiPSCs) with genomic and molecular technologies.
    link, url='https://www.linkedin.com/in/kitchdwilson/'
        image, url='https://framerusercontent.com/images/RNQYvKh86v7uqMWn2r987umoE.svg'
    image, url='https://framerusercontent.com/images/1M2vROqEngv8oo6VLWpeJSD4.png?scale-down-to=1024'
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        StaticText CTO
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        StaticText Evan Lyall, PhD
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        StaticText Evan is a UC Berkeley-trained Scientist-Engineer with over 10 years of experience in advanced microscopy, data engineering, and machine learning.
    link, url='https://www.linkedin.com/in/evlyall/'
        image, url='https://framerusercontent.com/images/RNQYvKh86v7uqMWn2r987umoE.svg'
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        StaticText SENIOR SCIENTIST
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        StaticText Aditya Khedkar, MS
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        StaticText Aditya is a Boston University- and Johns Hopkins-trained scientist with over 9 years of experience in gene editing and stem cell biology.
    link, url='https://www.linkedin.com/in/aditya-khedkar-a739b066/'
        image, url='https://framerusercontent.com/images/RNQYvKh86v7uqMWn2r987umoE.svg'
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        StaticText OPPORTUNITY
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        StaticText Interested in joining us?
    link Find a job opportunity, url='https://www.ycombinator.com/companies/rosebud-biosciences/jobs'
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        StaticText CONTACT US
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        StaticText Speak with a team member
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        StaticText Rosebud is a science-first organization that offers best-in-class products and technical support. Our team of experts is standing by to help you succeed.
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        StaticText Backed by
    link, url='https://www.ycombinator.com/companies/rosebud-biosciences'
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    link, url='https://seedfund.nsf.gov/awardees/history/details/?company=rosebud-biosciences-inc'
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        StaticText © 2024 Rosebud Biosciences Inc. 2024
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Reasoning for action: I decided to click the Play button of the embedded video because it is essential for engaging with the content presented by Rosebud Biosciences. The video is likely to provide a visual and auditory overview of their organoid technology and its applications, facilitating my understanding of their research methods and potential collaboration opportunities. By playing the video, I am moving closer to achieving the goal of deepening my knowledge about their innovative approaches.

Action: click(150) # Click on the Play button of the embedded video to learn more about their technology.

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